Raphael Mechoulam releases latest research

Published Oct 3, 2019 10:00 a.m. ET
iStock / Jose S

One of the latest cannabis information releases is straight from the head of research at EPM, and he is known as “the father of cannabis research,” Raphael Mechoulam. So, just who is this man? Well, he was born in 1930 in Sofia, Bulgaria, and his father was a physician.  Raphael received his M.Sc. in biochemistry from the Hebrew University of Jerusalem (1952), which he quickly followed with his Ph.D. in 1958, and 1994, saw him elected as a member of the Israel Academy of Sciences. Though decades have passed since the breakthrough discovery of THC, Raphael’s work at linking CBD  for the treatment of epilepsy has helped many children.

Latest research

His latest research shows promise in cannabidiol acid methyl ester (HU-580), and this scientific discovery could be more therapeutic in the treatment of depression than using CBD. It will also be beneficial in developing drugs for the treatment of arthritis, anxiety, psoriasis and inflammatory bowel disease. He hopes that his latest research will not be overlooked – again. He believes his new findings will have stronger therapeutic effects than CBD. He and his cannabis research team have developed a process for the creation of synthetic stable acids that are found within the cannabis plant. These synthetic acids include acid versions of THC and CBD which are now available to be licensed to companies for further drug development.

The results

The research has shown that the acids have produced no side-effects. The naturally occurring, although unstable CBD acid (CBDA) is a thousand times more potent than CBD, in binding to a particular serotonin receptor.  This is a receptor thought to be responsible for the alleviation of anxiety and nausea. This molecule has no side-effects and works just like a steroid. EPM's research seems to confirm what the positives of cannabis acids suspected by others.

Unfortunately, due to the instability, the fellow scientists have been unable to confirm the results. Ziva Cooper's research director of UCLA Cannabis Research Initiative adds that this discovery could be useful for pain control also. She states more testing is needed to determine safety for humans but is encouraged with EPM and Raphael Mechoulam results to date.


CBD oil side effects

Most people tolerate CBD oil quite well, however, there are some possible side-effects which are listed here. According to the Cannabis and Cannabinoid Research, these are the most commonly reported side-effects of using CBD oil.

  • Changes in one’s appetite
  • Weight gain or weight loss
  • ·Tiredness low energy feelings
  • Diarrhea upset stomach

Future cannabis research

Marijuana legalization in Canada has encouraged some of the large financial entities to open their purse strings and contribute to research into discovering the benefits of the natural cannabis plant. Universities in Canada are working in partnership with this scientist at the university in Israel to develop further advantages of this miraculous plant. The research is expected to continue over the long term, and Mechoulam hopes that the scientific community will take heed now. Too many delays were made in the acknowledgment of the benefits of CBD/THC and we should avoid making that mistake again, as it was not beneficial to the children that have since been helped with his earliest discoveries of the cannabis plant's health properties.

US awards 3M to fill gaps in medical marijuana research


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