What happens when you use cannabis and magic mushrooms together?

Published Feb 7, 2021 02:00 p.m. ET
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We have a pretty good understanding of what can happen when you combine cannabis with alcohol, even if we can’t yet predict exactly what will occur in the case of each individual, but there are new and more enticing substances hitting the scene. Psilocybin mushrooms, aka shrooms or magic mushrooms, are becoming quite popular, and many of those who are brave enough to take them are also cannabis enthusiasts.

This makes total sense. Both drugs grow from the ground, completely organic, and they’re gently processed in whole form for the consumer to enjoy. Of course, psilocybin mushrooms aren’t yet legal, but that isn’t stopping millions of users from getting their hands on them. The availability of shrooms has increased in recent years, especially since the medical community at large began accepting the medicinal benefits of the fungi, and now many people are wondering whether or not it’s safe to take both.

Just like it is with alcohol, mixing mushrooms and cannabis is a misunderstood art, but thanks to clinical trials and research, we do know a little bit about how the two substances can interact. The thing is that what you take, how to take it, and when you take the drugs make a significant difference in the possible outcome. To explain this is a way that more simply breaks down the process, we’re going to start way back at the beginning by revealing what each substance is capable of alone, and then we’ll work our way up from there.


Cannabis is the reason we’re all here because it’s the safest substance choice on the market today, and not just for our health. The mind can benefit greatly from green products, plus when they are inhaled, the effects are relatively short-lived, which makes it less likely for a consumer to be impaired while doing dangerous tasks such as driving. The effects which are often described as euphoric or sedating can also be uplifting, so it’s a unique buzz because it’s easy to control and it doesn’t last long.

Psilocybin mushrooms

The idea to try shrooms might be a tempting one, especially with all of the positive hype in the media, thanks to incredible discoveries by the medical community, which is quickly turning psilocybin into a far more popular substance. They seem to be safe, but the effects can be intense, overwhelming, and even go so far as to cause hallucinations. Though rare, a mushroom trip can last upwards of 4-8 hours which is more comparable to a THC edible than smoking, and the side effects that may be experienced from psilocybin can be completely debilitating and hard to control.

Mixing mushrooms and cannabis

Mixing these two incredibly different substances might seem like a good idea, and the truth is that it can be, if it’s executed by a skilled individual, preferably with a built tolerance to each drug separately, but there are a few things that can happen when you do this. In the end, it all comes down to when you take them and the timing for each one.

How CBD and THC interact with psilocybin

We don’t have a whole lot for research to look to when it comes to mixing cannabis with psilocybin mushrooms, but what we do have shows that mixing CBD with psilocybin can help to reduce some of the negative feelings and effects that can be caused by the mushrooms. THC-rich cannabis strains, on the other hand, seem to enhance the trip, making the effects more intense, which can lead to more vivid visual and auditory hallucinations.

Using cannabis before shrooms

Some people find that using cannabis before taking shrooms helps to ease nausea and anxiety that can be brought on by psilocybin. In some ways, this can help to prepare your body for the high, but sadly this doesn’t work for everyone.

Using cannabis when you’re high on magic mushrooms -

Many spend their whole lives seeking out the most intense high possible, and if that sounds like you, then you might want to consider taking cannabis approximately 2 hours after enjoying some shrooms. At this point, you’ll be at the peak of your buzz from the psilocybin mushrooms, so once the green kicks in, it will take over with a milder and yet still euphoric high, but for a short time, you’ll be higher than you’ve likely ever been in your life.

Is mixing mushrooms and cannabis safe?

Mushrooms can certainly make you regret taking them if you go overboard, but there is nothing inherently unsafe about mixing mushrooms and cannabis. As we’ve shown you, in some cases, it could be safer for the consumer to take a combination of the two substances rather than one at a time, but this all depends on your tolerance and reaction to psilocybin mushrooms and cannabis. If for whatever reason, the effects of either one doesn’t agree with you, the results achieved could be uncomfortable, to say the least.

It’s always best to play it safe

Psilocybin mushrooms and cannabis are safe recreational and medicinal drugs that can be enjoyed safely either apart or together, as long as they’re consumed responsibly, but it’s usually safest to err on the side of caution. No matter how appealing, the general recommendation is still to avoid mixing drugs of any sort because we still don’t quite yet fully understand what happens to the body when they come together.

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